ANGIOGENIC PEPTIDES IN PANCREATIC-ISLET TRANSPLANTATION TO DIABETIC RATS

被引：12

作者：

HAYEK, A

LOPEZ, AD

BEATTIE, GM

机构：

[1] Lucy Thorne Whittier Children’s Center, The Whittier Institute for Diabetes and Endocrinology, La Jolla, CA

来源：

TRANSPLANTATION | 1990年 / 50卷 / 06期

关键词：

D O I：

10.1097/00007890-199012000-00005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To overcome the deleterious effects of hyperglycemia on islet transplantation, we have used recombinant basic fibroblast growth factor (FGF), an angiogenic peptide, concurrently with the intrasplenic placement of neonatal islets in severely diabetic rats. In both experimental and control rats, a minipump, secured to the spleen with a small indwelling catheter, delivered either the basic FGF at 10 ng/hr, or only the diluent. The rate of cure in the animals receiving the islets plus the peptide was significantly higher (70%) than in control rats (20%). This difference (P < 0.05), could not be attributed to direct effects of the peptide on islet function or to increased islet cell replication. We believe that these results may be best explained as an enhancement by basic FGF of the angiogenic process in the transplant islets.

引用

页码：931 / 933

页数：3

共 12 条

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