PROGRAMMED LIPID-PEROXIDATION OF BIOMEMBRANES GENERATING KINKED PHOSPHOLIPIDS PERMITTING LOCAL MOLECULAR MOBILITY - A PEROXIDATIVE THEORY OF FLUIDITY MANAGEMENT

The lipid peroxidation profiles in the uterus of mature mice show cyclic alterations during the reproductive cycle. Similarity, during early pregnancy, alterations in lipid peroxidation are evident, keeping close pace with the superoxide anion radical levels and fluidity parameters reported elsewhere. This formulates a theory that a ′controlled′ lipid peroxidation of biomembrane terminating at the accumulation of cyclic endoperoxides could rather enhance local molecular mobility because of the increased inter-molecular distance in these ′kinked-species′. © 1993 Acdamic Press. Inc.