ROLE OF YEAST INSULIN-DEGRADING ENZYME HOMOLOGS IN PROPHEROMONE PROCESSING AND BUD SITE SELECTION

被引：109

作者：

ADAMES, N

BLUNDELL, K

ASHBY, MN

BOONE, C

机构：

[1] SIMON FRASER UNIV, INST BIOCHEM & MOLEC BIOL, BURNABY, BC V5A 1S6, CANADA

[2] UNIV CALIF BERKELEY, DEPT MOLEC & CELL BIOL, BERKELEY, CA 94720 USA

来源：

SCIENCE | 1995年 / 270卷 / 5235期

关键词：

D O I：

10.1126/science.270.5235.464

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Saccharomyces cerevisiae AXL1 gene product Axl1p shares homology with the insulin-degrading enzyme family of endoproteases. Yeast axl1 mutants showed a defect in a-factor pheromone secretion, and a probable site of processing by Axl1p was identified within the a-factor precursor. In addition, Axl1p appears to function as a morphogenetic determinant for axial bud site selection. Amino acid substitutions within the presumptive active site of Axl1p caused defects in propheromone processing but failed to perturb bud site selection. Thus, Axl1p has been shown to participate in the dual regulation of distinct signaling pathways, and a member of the insulinase family has been implicated in propeptide processing.

引用

页码：464 / 467

页数：4

共 50 条

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