MOLECULAR-CLONING OF RAT BONE MORPHOGENETIC PROTEIN (BMP) TYPE IA RECEPTOR AND ITS EXPRESSION DURING ECTOPIC BONE-FORMATION INDUCED BY BMP

被引：34

作者：

TAKEDA, K

OIDA, S

ICHIJO, H

IIMURA, T

MARUOKA, Y

AMAGASA, T

SASAKI, S

机构：

[1] TOKYO MED & DENT UNIV,DEPT BIOCHEM,BUNKYO KU,TOKYO 113,JAPAN

[2] TOKYO MED & DENT UNIV,DEPT ORAL & MAXILLOFACIAL SURG 1,BUNKYO KU,TOKYO 113,JAPAN

[3] TOKYO MED & DENT UNIV,DEPT ORAL & MAXILLOFACIAL SURG 2,BUNKYO KU,TOKYO 113,JAPAN

[4] TOKYO MED & DENT UNIV,DEPT ORAL PATHOL,BUNKYO KU,TOKYO 113,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 204卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.2445

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cDNA for the rat bone morphogenetic protein (BMP) type IA receptor (BMPR-IA) was isolated from a dental pulp cell cDNA library. The rat BMPR-IA cDNA encodes a protein of 532 amino acids with a single transmembrane domain and a putative serine/threonine kinase domain. The overall amino acid sequence identity between the rat and human BMPR-IA was 97 %. Reverse transcriptase-polymerase chain reaction analysis revealed that BMPR-IA mRNA was highly expressed in the BMP-induced bone forming tissues throughout the stages tested. (C) 1994 Academic Press, Inc.

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页码：203 / 209

页数：7

相关论文

共 26 条

[1] NOVEL ACTIVIN RECEPTORS - DISTINCT GENES AND ALTERNATIVE MESSENGER-RNA SPLICING GENERATE A REPERTOIRE OF SERINE THREONINE KINASE RECEPTORS [J].

ATTISANO, L ;

WRANA, JL ;

CHEIFETZ, S ;

MASSAGUE, J .

CELL, 1992, 68 (01) :97-108

[2] IDENTIFICATION OF HUMAN ACTIVIN AND TGF-BETA TYPE-I RECEPTORS THAT FORM HETEROMERIC KINASE COMPLEXES WITH TYPE-II RECEPTORS [J].

ATTISANO, L ;

CARCAMO, J ;

VENTURA, F ;

WEIS, FMB ;

MASSAGUE, J ;

WRANA, JL .

CELL, 1993, 75 (04) :671-680

[3] IDENTIFICATION OF TRANSFORMING GROWTH-FACTOR-BETA FAMILY MEMBERS PRESENT IN BONE-INDUCTIVE PROTEIN PURIFIED FROM BOVINE BONE [J].

CELESTE, AJ ;

IANNAZZI, JA ;

TAYLOR, RC ;

HEWICK, RM ;

ROSEN, V ;

WANG, EA ;

WOZNEY, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (24) :9843-9847

[4]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[5] DETERMINATION OF TYPE-I RECEPTOR SPECIFICITY BY THE TYPE-II RECEPTORS FOR TGF-BETA OR ACTIVIN [J].

EBNER, R ;

CHEN, RH ;

LAWLER, S ;

ZIONCHECK, T ;

DERYNCK, R .

SCIENCE, 1993, 262 (5135) :900-902

[6] CLONING OF A TGF-BETA TYPE-I RECEPTOR THAT FORMS A HETEROMERIC COMPLEX WITH THE TGF-BETA TYPE-II RECEPTOR [J].

FRANZEN, P ;

TENDIJKE, P ;

ICHIJO, H ;

YAMASHITA, H ;

SCHULZ, P ;

HELDIN, CH ;

MIYAZONO, K .

CELL, 1993, 75 (04) :681-692

[7] THE PROTEIN-KINASE FAMILY - CONSERVED FEATURES AND DEDUCED PHYLOGENY OF THE CATALYTIC DOMAINS [J].

HANKS, SK ;

QUINN, AM ;

HUNTER, T .

SCIENCE, 1988, 241 (4861) :42-52

[8] CHONDROGENESIS AND OSTEOGENESIS OF BONE MARROW-DERIVED CELLS BY BONE-INDUCTIVE FACTOR [J].

HARADA, K ;

OIDA, S ;

SASAKI, S .

BONE, 1988, 9 (03) :177-183

[9] CHANGES IN HOMEOBOX-CONTAINING GENE-EXPRESSION DURING ECTOPIC BONE-FORMATION INDUCED BY BONE MORPHOGENETIC PROTEIN [J].

IIMURA, T ;

OIDA, S ;

TAKEDA, K ;

MARUOKA, Y ;

SASAKI, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 201 (02) :980-987

[10] ESTABLISHMENT AND CHARACTERIZATION OF A CLONAL CELL-LINE (RPC-C2A) FROM DENTAL-PULP OF THE RAT INCISOR [J].

KASUGAI, S ;

ADACHI, M ;

OGURA, H .

ARCHIVES OF ORAL BIOLOGY, 1988, 33 (12) :887-891