META .2. A DICTIONARY MODEL OF MAMMALIAN XENOBIOTIC METABOLISM

被引：78

作者：

TALAFOUS, J

SAYRE, LM

MIEYAL, JJ

KLOPMAN, G

机构：

[1] CASE WESTERN RESERVE UNIV,DEPT CHEM,CLEVELAND,OH 44106

[2] CASE WESTERN RESERVE UNIV,DEPT PHARMACOL,CLEVELAND,OH 44106

来源：

JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES | 1994年 / 34卷 / 06期

关键词：

D O I：

10.1021/ci00022a015

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

META is a new knowledge-based expert system that provides computer simulation of the biotransformation of chemicals. The program is based on the recognition of key functional groups within the complete chemical structure and therefore can predict the metabolites of new xenobiotics. Here, we describe a comprehensive knowledge base built for the purposes of modeling mammalian metabolism with META methodology.

引用

页码：1326 / 1333

页数：8

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