SOS-REGULATED PROTEINS IN TRANSLESION DNA-SYNTHESIS AND MUTAGENESIS

被引：90

作者：

WALKER, GC

机构：

[1] Department of Biology, Massachusetts Institute of Technology, Cambridge

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1995年 / 20卷 / 10期

关键词：

D O I：

10.1016/S0968-0004(00)89091-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Studies of Escherichia coli have revealed that most mutagenesis resulting from exposure to UV radiation and various chemicals (SOS mutagenesis) requires the operation of a specialized system involving the UmuD', UmuC, RecA and DNA polymerase III proteins, which allows translesion synthesis to occur on damaged DNA templates. The SOS mutagenesis system is induced by DNA damage and is subject to elaborate regulatory control involving both transcriptional derepression and post-translational activation and inhibition. The implications of the E. coli SOS mutagenesis system for mutagenesis in other organisms are discussed.

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页码：416 / 420

页数：5

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