ANALYSIS AND SIMULATION OF HOLLOW-FIBER BIOREACTOR DYNAMICS

被引：28

作者：

KLEINSTREUER, C

AGARWAL, SS

机构：

[1] North Carolina State Univ, Raleigh,, NC, USA, North Carolina State Univ, Raleigh, NC, USA

来源：

BIOTECHNOLOGY AND BIOENGINEERING | 1986年 / 28卷 / 08期

关键词：

BIOCHEMICAL ENGINEERING - Computer Simulation - FIBERS; NONTEXTILE; -; Applications;

D O I：

10.1002/bit.260280815

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A flexible and economical computer simulation model for the process analysis, parameter prediction, and optimal design of hollow-fiber biochemical reactors (HFBRs) has been developed. The validity and predictive capability of the HFBR simulator was successfully tested with two independent laboratory case studies. Of particular interest are the transient transport and bioconversion mechanisms including the effect of radial mass convection on the substrate uptake in the lumen. The portable computer code is an efficient tool to aid in theoretical and experimental investigations. The underlying principles used for the model development are applicable to a broad family of (membrane) bioreactors.

引用

页码：1233 / 1240

页数：8

共 18 条

[1] Bailey J., 1984, BIOCH ENG FUNDAMENTA, V2nd
[2] DYNAMICS OF BIOFILM PROCESSES - METHODS
CHARACKLIS, WG
TRULEAR, MG
BRYERS, JD
ZELVER, N
[J]. WATER RESEARCH, 1982, 16 (07) : 1207 - 1216
[3] KINETICS STUDIES IN A CONTINUOUS STEADY-STATE HOLLOW FIBER MEMBRANE ENZYME REACTOR
DAVIS, JC
[J]. BIOTECHNOLOGY AND BIOENGINEERING, 1974, 16 (08) : 1113 - 1122
[4] HOLLOW FIBER ENZYME REACTORS FOR MALTOSE AND STARCH HYDROLYSIS
ENGASSER, JM
CAUMON, J
MARC, A
[J]. CHEMICAL ENGINEERING SCIENCE, 1980, 35 (1-2) : 99 - 105
[5] BETA-GALACTOSIDASE RETENTION BY HOLLOW FIBER MEMBRANES
HUFFMANREICHENBACH, LM
HARPER, WJ
[J]. JOURNAL OF DAIRY SCIENCE, 1982, 65 (06) : 887 - 898
[6] HOLLOW-FIBER MEMBRANE BIOREACTORS USING IMMOBILIZED ESCHERICHIA-COLI FOR PROTEIN-SYNTHESIS
INLOES, DS
SMITH, WJ
TAYLOR, DP
COHEN, SN
MICHAELS, AS
ROBERTSON, CR
[J]. BIOTECHNOLOGY AND BIOENGINEERING, 1983, 25 (11) : 2653 - 2681
[7] KIM SS, 1976, CHEM ENG SCI, V31, P289, DOI 10.1016/0009-2509(76)85074-9
[8] COMPUTER-SIMULATION OF TRANSPORT PHENOMENA DURING DIALYSIS DEGLYCEROLIZATION OF RED-BLOOD-CELLS
KLEINSTREUER, C
PALLER, M
PONZIO, RJ
[J]. COMPUTERS AND BIOMEDICAL RESEARCH, 1983, 16 (01): : 29 - 39
[9] KLEINSTREUER C, 1984, SYNTHETIC MEMBRANE P
[10] KLEINSTREUER C, 1984, NOV P AICHE ANN M SA

← 1 2 →