IMMUNOCHEMICAL STUDIES OF MYELIN BASIC-PROTEIN IN SHIVERER MOUSE DEVOID OF MAJOR DENSE LINE OF MYELIN

被引：175

作者：

DUPOUEY, P

JACQUE, C

BOURRE, JM

CESSELIN, F

PRIVAT, A

BAUMANN, N

机构：

[1] HOP SALPETRIERE, CNRS,INSERM,NEUROCHIM LAB,EQUIPE RECH 421,U 134, F-75634 PARIS 13, FRANCE

[2] FAC MED PITIE SALPETRIERE, SERV BIOCHIM, F-75013 PARIS, FRANCE

[3] INSERM, CULTURE TISSU NERVEUX LAB, U 106, F-75014 PARIS, FRANCE

来源：

NEUROSCIENCE LETTERS | 1979年 / 12卷 / 01期

关键词：

D O I：

10.1016/0304-3940(79)91490-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The myelin-deficient mutant Shiverer (Shi/Shi) lacks basic protein (MBP) in the myelin of its central nervous system (CNS). Less than 3% of the normal content in MBP is present in a brain extract of Shi/Shi as determined by radioimmunoassay. Indirect immunofluorescence is negative when using specific anti-MBP serum. The importance of Shi/Shi (as compared to other hypomelinating mutants) stems from the specificity of this genetic lesion, i.e. the lack of basic protein. © 1979.

引用

页码：113 / 118

页数：6

共 24 条

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