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PROPORTION OF DNA GYRASE MUTANTS AMONG QUINOLONE-RESISTANT STRAINS OF PSEUDOMONAS-AERUGINOSA

被引：70
作者：
YOSHIDA, H
NAKAMURA, M
BOGAKI, M
NAKAMURA, S
机构：
[1] Research Laboratories, Dainippon Pharmac. Co., Ltd., Osaka 564
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 06期
关键词：
D O I：
10.1128/AAC.34.6.1273
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The proportion of DNA gyrase mutants among quinolone-resistant strains of Pseudomonas aeruginosa was examined by introducing the cloned wild-type Escherichia coli gyrA and gyrB genes. Of 101 spontaneous mutants of P. aeruginosa PAO505, 33 (33%) were found to have gyrA mutations. Among 17 clinical isolates, 12 (71%) had gyrA mutations and 1 (6%) had a gyrB mutation.
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页码：1273 / 1275
页数：3
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