TROPHIC EFFECT OF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR ON CENTRAL CHOLINERGIC NEURONS INVITRO

被引：41

作者：

KAMEGAI, M ^{[1
]}

KONISHI, Y ^{[1
]}

TABIRA, T ^{[1
]}

机构：

[1] NATL CTR NEUROL & PSYCHIAT,NATL INST NEUROSCI,DIV DEMYELINATING DIS,4-1-1 OGAWAHIGASHI,KODAIRA,TOKYO 187,JAPAN

来源：

BRAIN RESEARCH | 1990年 / 532卷 / 1-2期

关键词：

Cholinergic; Granulocyte-macrophage colony-stimulating factor; Interleukin-3; Septal neuron;

D O I：

10.1016/0006-8993(90)91775-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Granulocyte-macrophage colony-stimulating factor (GM-CSF) elevated choline acetyltransferase (ChAT) activities of mouse septal neurons as well as of cholinergic hybridoma line cells SN6.10.2.2 in vitro. It augmented ChAT activities and neurite extension of interleukin 3-activated cholinergic neurons. Thus, GM-CSF should be added as a trophic factor for central cholinergic neurons. © 1990.

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页码：323 / 325

页数：3

相关论文

共 13 条

[1]

BURGESS AW, 1980, BLOOD, V56, P947

[2] CLONING, SEQUENCE, AND EXPRESSION OF A HUMAN GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR [J].

CANTRELL, MA ;

ANDERSON, D ;

CERRETTI, DP ;

PRICE, V ;

MCKEREGHAN, K ;

TUSHINSKI, RJ ;

MOCHIZUKI, DY ;

LARSEN, A ;

GRABSTEIN, K ;

GILLIS, S ;

COSMAN, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (18) :6250-6254

[3] THE HUMAN HEMATOPOIETIC COLONY-STIMULATING FACTORS [J].

CLARK, SC ;

KAMEN, R .

SCIENCE, 1987, 236 (4806) :1229-1237

[4] RAPID RADIOCHEMICAL METHOD FOR DETERMINATION OF CHOLINE-ACETYLTRANSFERASE [J].

FONNUM, F .

JOURNAL OF NEUROCHEMISTRY, 1975, 24 (02) :407-409

[5] MOLECULAR-CLONING OF CDNA-ENCODING A MURINE HEMATOPOIETIC GROWTH-REGULATOR, GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR [J].

GOUGH, NM ;

GOUGH, J ;

METCALF, D ;

KELSO, A ;

GRAIL, D ;

NICOLA, NA ;

BURGESS, AW ;

DUNN, AR .

NATURE, 1984, 309 (5971) :763-767

[6] STRUCTURE AND EXPRESSION OF THE MESSENGER-RNA FOR MURINE GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR [J].

GOUGH, NM ;

METCALF, D ;

GOUGH, J ;

GRAIL, D ;

DUNN, AR .

EMBO JOURNAL, 1985, 4 (03) :645-653

[7] NEURONAL PROPERTIES OF CLONAL HYBRID CELL-LINES DERIVED FROM CENTRAL CHOLINERGIC NEURONS [J].

HAMMOND, DN ;

WAINER, BH ;

TONSGARD, JH ;

HELLER, A .

SCIENCE, 1986, 234 (4781) :1237-1240

[8]

HORIGUCHI J, 1987, BLOOD, V69, P1259

[9] INTERLEUKIN-3 AS A TROPHIC FACTOR FOR CENTRAL CHOLINERGIC NEURONS INVITRO AND INVIVO [J].

KAMEGAI, M ;

NIIJIMA, K ;

KUNISHITA, T ;

NISHIZAWA, M ;

OGAWA, M ;

ARAKI, M ;

UEKI, A ;

KONISHI, Y ;

TABIRA, T .

NEURON, 1990, 4 (03) :429-436

[10] ISOLATION OF CDNA FOR A HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR BY FUNCTIONAL EXPRESSION IN MAMMALIAN-CELLS [J].

LEE, F ;

YOKOTA, T ;

OTSUKA, T ;

GEMMELL, L ;

LARSON, N ;

LUH, J ;

ARAI, KI ;

RENNICK, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (13) :4360-4364