MACROCYTOSIS AS A CONSEQUENCE OF ALCOHOL-ABUSE AMONG PATIENTS IN GENERAL-PRACTICE

被引:38
作者
SEPPA, K [1 ]
LAIPPALA, P [1 ]
SAARNI, M [1 ]
机构
[1] HATANPAA HOSP,TAMPERE,FINLAND
关键词
ALCOHOL QUESTIONNAIRE; ERYTHROCYTE MEAN CELL VOLUME (MCV); COULTER COUNTER; FOLATE; MARROW VACUOLES;
D O I
10.1111/j.1530-0277.1991.tb00615.x
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Macrocytosis, a common finding in patients without anemia or other hematologic abnormalities, is often ignored. The purpose of this prospective study was to investigate 300 consecutive, adult health-center patients with a mean cell volume (MCV) value greater-than-or-equal-to 100 fl. The incidence of macrocytosis was 2.4%. Of the 177 male and 123 female patients, only 14 (4.7%) were anemic; 80.2% of the men (89.3% of those under 60 years) and 34.1% of the women were alcohol abusers, representing the largest diagnostic group. The highest MCV value found in alcoholics without folate or vitamin B-12 deficiency was 120 fl. The most useful laboratory test for identifying alcohol abuse among macrocytic patients was the measurement of serum gammaglutamyltransferase. Of the several morphologic abnormalities in the marrow the only specific finding were vacuoles in the granulocyte or erythrocyte precursors. No underlying cause was found for macrocytosis in 6.8% of the men and 35.8% of the women. Even when it is not associated with anemia, macrocytosis should not be ignored. It may be the only indicator of a disease which often, particularly in young and middle-aged men, is alcohol abuse.
引用
收藏
页码:871 / 876
页数:6
相关论文
共 41 条
[1]   DO HOUSEMEN TAKE AN ADEQUATE DRINKING HISTORY [J].
BARRISON, IG ;
VIOLA, L ;
MURRAYLYON, IM .
BRITISH MEDICAL JOURNAL, 1980, 281 (6247) :1040-1040
[2]   The anemia of alcohol addicts - Observations as to the role of liver disease, achlorhydria, nutritional factors and alcohol on its production [J].
Bianco, A ;
Jolliffe, N .
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1938, 196 (03) :414-420
[3]  
BREEDVELD FC, 1981, ACTA MED SCAND, V209, P319
[4]   THE HEMOGRAM AND THE DIAGNOSIS OF ALCOHOLISM [J].
CARNEY, MWP ;
SHEFFIELD, BF .
JOURNAL OF STUDIES ON ALCOHOL, 1980, 41 (07) :744-748
[5]   SEX-RELATED DIFFERENCES IN THE HEMATOLOGICAL EFFECTS OF EXCESSIVE ALCOHOL-CONSUMPTION [J].
CHALMERS, DM ;
CHANARIN, I ;
MACDERMOTT, S ;
LEVI, AJ .
JOURNAL OF CLINICAL PATHOLOGY, 1980, 33 (01) :3-7
[6]   HEMATOPOIESIS AND ALCOHOL [J].
CHANARIN, I .
BRITISH MEDICAL BULLETIN, 1982, 38 (01) :81-86
[7]  
CHICK J, 1987, ALCOHOL ALCOHOLISM, V22, P75
[8]  
CHICK J, 1981, LANCET, V1, P1249
[9]  
Coulter W. H., 1956, P NATIONAL ELECTRONI, V12, P1034, DOI DOI 10.1038/366591A0
[10]   A DEVICE FOR COUNTING SMALL PARTICLES SUSPENDED IN A FLUID THROUGH A TUBE [J].
CROSLANDTAYLOR, PJ .
NATURE, 1953, 171 (4340) :37-38