CYCLOSPORINE-INDUCED GRAFT-VERSUS-HOST DISEASE AFTER AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN HEMATOLOGICAL MALIGNANCIES

被引：30

作者：

CARELLA, AM ^{[1
]}

GAOZZA, E ^{[1
]}

CONGIU, A ^{[1
]}

CARLIER, P ^{[1
]}

NATI, S ^{[1
]}

TRUINI, M ^{[1
]}

CASTELLANETA, A ^{[1
]}

VIALE, M ^{[1
]}

机构：

[1] SAN MARTINO HOSP,DIV HAEMATOL 2,ONCOHEMATOL & ABMT UNIT,GENOA,ITALY

来源：

ANNALS OF HEMATOLOGY | 1991年 / 62卷 / 05期

关键词：

CYA; ABMT IN HEMATOLOGICAL NEOPLASIAS; GVHD;

D O I：

10.1007/BF01703140

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In the attempt to induce graft-vs-host disease (GVHD) in patients undergoing autologous bone marrow transplantation (ABMT) or blood stem cell transplantation (BSCT), 12 consecutive patients received cyclosporin A (CyA) post transplant. CyA was given at a dose of 1.5 mg/kg/day intravenously for 28 days, starting on the day of transplant. Histologically proven acute GVHD of the skin occurred in seven patients 9-14 days after ABMT and lasted 7-11 days. CyA-induced GVHD after ABMT resembles mild GVHD after allogeneic bone marrow transplantation (BMT). Although the preliminary data reported here show that it is possible to induce GVHD in patients undergoing ABMT, it is not yet known whether GVHD after ABMT will have an antitumor activity.

引用

页码：156 / 159

页数：4

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