LASER-INDUCED HYPERTHERMIA - COMPARISON OF 2 DIFFERENT METHODS

被引:15
作者
CASTRENPERSONS, M
LIPASTI, J
PUOLAKKAINEN, P
SCHRODER, T
机构
[1] UNIV HELSINKI,CENT HOSP,DEPT SURG 2,SF-00290 HELSINKI 29,FINLAND
[2] UNIV TURKU,DEPT FORENS MED,SF-20500 TURKU 50,FINLAND
关键词
ND-YAG LASER; HYPERTHERMIA; LIVER;
D O I
10.1002/lsm.1900120616
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The effectiveness of two different techniques of laser-induced hyperthermia was analyzed in healthy piglet livers. Hyperthermia was produced using a continuous-wave Nd:YAG laser with both a contact sapphire probe and a bare quartz fibre. In both methods the tip was inserted into the liver, and the temperature 1 cm from the tip was raised and held between 42-degrees-C and 44-degrees-C for 600 seconds. Specimens were taken 0, 7 and 14 days after the treatment. The tissue effects of 36 treatment sites were analysed using standard van Gieson's method. In addition, a histochemical method for demonstrating lactate dehydrogenase activity was employed to show damage not observable by routine methods. No statistically significant difference in the extent of the treatment sites at d 0 and after 7 days was seen when comparing the two laser methods. After 2 weeks, the diameter of the lesion with the bare fibre was significantly larger (3,7 mm with both analysing methods) than by using the contact probe (2,6 with LDH demonstration; P < 0.01 and 2,1 mm with van Gieson's staining; P < 0.001). It can be concluded that the simple fibre tip seems more effective in causing tissue necrosis than the sapphire tip.
引用
收藏
页码:665 / 668
页数:4
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