MYCOPLASMA-FERMENTANS (INCOGNITUS STRAIN) INDUCES TNF-ALPHA AND IL-1 PRODUCTION BY HUMAN MONOCYTES AND MURINE MACROPHAGES

被引：31

作者：

GALLILY, R ^{[1
]}

SALMAN, M ^{[1
]}

TARSHIS, M ^{[1
]}

ROTTEM, S ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT MEMBRANE & ULTRASTRUCT RES,IL-91010 JERUSALEM,ISRAEL

来源：

IMMUNOLOGY LETTERS | 1992年 / 34卷 / 01期

关键词：

MYCOPLASMA-FERMENTANS; CYTOKINE PRODUCTION; STIMULATION OF; MONOCYTE; MACROPHAGE;

D O I：

10.1016/0165-2478(92)90023-H

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have demonstrated that Mycoplasma fermentans (incognitus strain), as well as M. fermentans KL4, PG 18 and IM 1 strains have the ability to activate human peripheral blood monocytes and murine macrophages of two inbred strains to secrete a high level of tumor necrosis factor alpha (TNFalpha) in a dose-dependent manner. Secretion of interleukin-1 (IL-1) was also stimulated following the incubation of human monocytes with the organism. We suggest that cytokine secretion following infection with M. fermentans (incognitus strain) that was detected in AIDS patients may contribute to the pathological manifestations, including cachexia, in this disease.

引用

页码：27 / 30

页数：4

共 27 条

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