IMMUNE-RESPONSE TO SIMULTANEOUS ADMINISTRATION OF A COMBINED MEASLES, MUMPS AND RUBELLA VACCINE WITH BOOSTER DOSES OF DIPHTHERIA-TETANUS AND POLIOVIRUS VACCINE

被引：11

作者：

GIAMMANCO, G

LIVOLTI, S

SALEMI, I

BILANCIA, GG

MAURO, L

机构：

[1] Institute of Hygiene and Preventive Medicine, University of Catania, Catania, 4 95124, Via Biblioteca

[2] Department of Pediatrics, University of Catania, Catania, 6 - 95125, Viale Andrea Doria

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 1993年 / 9卷 / 02期

关键词：

MEASLES; MUMPS; RUBELLA; COMBINED VACCINE; COMPULSORY VACCINES; SIMULTANEOUS ADMINISTRATION;

D O I：

10.1007/BF00158792

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A combined vaccine against measles (Edmonston-Zagreb 19 strain), mumps (Rubini strain) and rubella (Wistar RA 27/3 strain) was administered to a group of 46 children aged 10-12 months simultaneously with booster doses of compulsory diphtheria-tetanus toxoid and oral poliovirus vaccine. A second group of 53 children aged 15-24 months who had received booster doses of the compulsory vaccines 5 to 12 months before was also vaccinated. The same seroconversion rates (100%) and similar antibody titers for rubella were observed in both groups. The same seroconversion rates for mumps (93%) and similar rates for measles (98 and 94%) were observed in the two groups. Significantly lower antibody titers for measles and mumps were found in the first group, but they were compensated by an earlier protection, a reduction of number of visits for immunization, costs for the community, and improvement in parental compliance. These results confirm that Edmonston-Zagreb 19 and Rubini strains are still immunogenic even when they are combined with Wistar RA 27/3 strain. Moreover, a long term follow-up in order to verify the persistence of protective antibody levels in both groups of children, could suggest that combined measles, mumps and rubella vaccine could be given earlier (at 10-12 months of age), simultaneously with booster doses of diphtheria and tetanus toxoid and of trivalent oral poliovirus vaccine.

引用

页码：199 / 202

页数：4

共 19 条

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