A BIOCATALYTIC APPROACH TO NONRACEMIC 2-METHYL-3-(2-THIOPHENE)-1-PROPANOLS AS CHIRAL BUILDING-BLOCKS FOR THE SYNTHESIS OF PYRIDINE ALKALOIDS

被引：12

作者：

BRACHER, F

PAPKE, T

机构：

[1] Institut für Pharmazeutische Chemie, Technische Universität Braunschweig, 38106 Braunschweig

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 09期

关键词：

D O I：

10.1016/0957-4166(94)80073-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(S)-2-Methyl-3-(2-thiophene)-1-propanol was prepared by an improved baker's yeast-mediated asymmetric reduction of the corresponding 2,3-unsaturated aldehyde. (R)-2-Methyl-3(2-thiophene)-1-propanol was obtained by enzymatic kinetic resolution of the racemic alcohol in an organic solvent. Both enantiomers are versatile chiral building blocks for the synthesis of 3-alkyl pyridine alkaloids.

引用

页码：1653 / 1656

页数：4

共 12 条

[1] ENZYME-CATALYZED REACTIONS .17. LIPASE-CATALYZED RESOLUTION OF RACEMIC 2-ALKYL SUBSTITUTED 1-ALKANOLS [J].