HOW ASPIRIN MIGHT WORK - A PHARMACOKINETIC APPROACH

被引：3

作者：

BRUNE, K

机构：

[1] Dept. of Pharmacology, Biocenter of the University, Basel, CH-4056

来源：

AGENTS AND ACTIONS | 1994年 / 43卷 / 3-4期

关键词：

D O I：

10.1007/BF01986692

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A pharmacokinetic interpretation of the effects and side-effects of acidic non-steroid anti-inflammatory drugs is presented. It is based on the general principles of drug action and leads to the conclusion that aspirin-like drugs should specifically accumulate and exert pharmacological activity in inflamed tissue, stomach and kidney. Therefore the common effects and side-effects of these drugs may result from unspecific effects in these compartments and might not necessarily be due to specific, i.e., receptor mediated action(s).

引用

页码：218 / 220

页数：3

共 31 条

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