The role of regenerative cell proliferation in chloroform-induced cancer

被引：26

作者：

Butterworth, BE

Templin, MV

Borghoff, SJ

Conolly, RB

Kedderis, GL

Wolf, DC

机构：

[1] Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709

来源：

TOXICOLOGY LETTERS | 1995年 / 82-3卷

关键词：

chloroform; nongenotoxic carcinogen; cell proliferation; risk assessment;

D O I：

10.1016/0378-4274(95)03543-5

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Chloroform produces cancer by a nongenotoxic-cytotoxic mode of action, with no increased cancer risk expected at noncytotoxic doses. The default risk assessment for inhaled chloroform relies on liver tumor incidence from a gavage study with female B6C3F(1) mice and estimates a virtually safe dose (VSD) at an airborne concentration of 0.000008 ppm of chloroform. In contrast, a 1000-fold safety factor applied to the NOAEL for liver cytotoxicity from inhalation studies yields a VSD of 0.01 ppm. This estimate relies on inhalation data and is more consistent with the mode of action of chloroform.

引用

页码：23 / 26

页数：4

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