STEREOSPECIFIC EFFECTS OF (-)SULPIRIDE ON BRAIN DOPAMINE METABOLISM AND PROLACTIN-RELEASE

被引：18

作者：

HOFMANN, M ^{[1
]}

JOMMI, GC ^{[1
]}

MONTEFUSCO, O ^{[1
]}

TONON, GC ^{[1
]}

SPANO, PF ^{[1
]}

TRABUCCHI, M ^{[1
]}

机构：

[1] UNIV MILAN, DEPT ORGAN CHEM, I-20133 MILAN, ITALY

来源：

JOURNAL OF NEUROCHEMISTRY | 1979年 / 32卷 / 05期

关键词：

D O I：

10.1111/j.1471-4159.1979.tb11097.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— Sulpiride, an unusual neuroleptic, was resolved into its two enantiomers by a newly developed procedure. (‐)Sulpiride is several times more active than (+)sulpiride in increasing rat prolactin secretion and DOPAC concentrations in rat strialum and limbic areas. These results are in agreement with clinical data showing that (‐)sulpiride is the active form of the drug. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：1547 / 1550

页数：4

共 19 条

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