SEROTYPE-1 REASSORTANT OF BOVINE ROTAVIRUS WC3, STRAIN WI79-9, INDUCES A POLYTYPIC ANTIBODY-RESPONSE IN INFANTS

被引：25

作者：

CLARK, HF ^{[1
]}

BORIAN, FE ^{[1
]}

MODESTO, K ^{[1
]}

PLOTKIN, SA ^{[1
]}

机构：

[1] CHILDRENS HOSP PHILADELPHIA, DIV INFECT DIS, PHILADELPHIA, PA 19104 USA

来源：

VACCINE | 1990年 / 8卷 / 04期

关键词：

reassortant; Rotavirus; vaccine; WI79-9;

D O I：

10.1016/0264-410X(90)90089-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A reassortant rotavirus, strain W179-9, was constructed bearing gene 9 of serotype 1 rotavirus strain W179 and all other genes derived from bovine (serotype 6) rotavirus strain WC3. The antigenic phenotype of W179-9 is bivalent: serotype 1 and serotype 6. W179-9 administered orally at a dose of 107.5 p.f.u. induced no adverse effects in 48 infants of age 2-11 months. Serotype 1- and serotype 6-specific serum neutralizing antibody titres were induced with approximately equal frequency in these infants. Serotype 1-specific antibody responses were inhibited in infants previously seropositive to type 1. The immune response rate was enhanced by administration of a second, 'booster dose'. © 1990.

引用

页码：327 / 332

页数：6

共 25 条

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