METABOLIC-FATE OF N-ISOPROPYL-N-PHENYLOXAMIC ACID IN THE RAT AND THE MILK GOAT

被引：1

作者：

BAKKE, JE

PRICE, CE

机构：

[1] Metabolism and Radiation Research Laboratory Federal Research, Science and Education Administration, U. S. Department of Agriculture, Fargo, North Dakota

来源：

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES | 1979年 / 14卷 / 03期

关键词：

metabolism; propachlor;

D O I：

10.1080/03601237909372128

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Rats excreted the 14C from a single oral dose of N-isopropyl-14 N-[14C]phenyloxamic acid [I, a soil metabolite from 2-chloro-N-isopropylacetanilide (propachlor)] in approximately equal quantities in the urine (49.2%) and feces (48.2%). A milking goat given daily oral doses of [14C]-I (1 mg of I three times daily) excreted more 14C in the feces (53.6%) than it excreted in the urine. From both species, I accounted for 97 to 100% of the urinary 14C, and all of the 14C that was extractable from the feces (73 to 75% of the 14C in feces was extractable with meth-anol). Goat milk samples collected 16 hr after the last dose contained no detectable 14C. Tissue residues of 14C were deter-mined. © 1979, Taylor & Francis Group, LLC

引用

页码：279 / 290

页数：12