INDUCTION OF ACETYLCHOLINE RECEPTORS ON CULTURED SKELETAL-MUSCLE BY A FACTOR EXTRACTED FROM BRAIN AND SPINAL-CORD

被引：256

作者：

JESSELL, TM

SIEGEL, RE

FISCHBACH, GD

机构：

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 10期

关键词：

D O I：

10.1073/pnas.76.10.5397

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Extracts of chicken brain and spinal cord increase the total number of acetylcholine receptors and the number of receptor clusters on uninnervated skeletal myotubes in culture. The active component in these extracts may be unique to neural tissue. Spinal cord cells grown in culture contain the active factor and they secrete it into the medium. Most of the activity is associated with a small molecule, possibly a peptide. Such a factor may be responsible for the clustering of receptors at newly formed nerve-muscle synapses.

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页码：5397 / 5401

页数：5

相关论文

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