MECHANISM OF PRODUCTION OF SINGLET OXYGEN ON PHOTOEXCITATION OF DRUGS INDUCING PHOTOSENSITIVITY

被引：6

作者：

ARAI, T

NISHIMURA, Y

SASAKI, M

FUJITA, H

MATSUO, I

SAKURAGI, H

TOKUMARU, K

机构：

[1] TOKAI UNIV, INST RES & DEV, HIRATSUKA, KANAGAWA 25912, JAPAN

[2] UNIV TSUKUBA, DEPT CHEM, SAKURA, IBARAKI 305, JAPAN

[3] TOKAI UNIV, SCH MED, ISEHARA, KANAGAWA 25911, JAPAN

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1991年 / 64卷 / 07期

关键词：

D O I：

10.1246/bcsj.64.2169

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The mechanism and active species of drug-induced photosensitive reactions were investigated by measuring the absorption spectra of the transient species on photoexcitation as well as by determining the efficiency of singlet oxygen production on quenching by oxygen of the excited state of drugs. The quantum yields of singlet oxygen production were determined for chlorpromazine hydrochloride, mequitazine, and afloqualone as 0.27, 0.28, and 0.14, respectively. These rather high yields of singlet oxygen suggest its important role in photosensitivity of the drugs. On the basis of the transient-spectroscopic investigations the quenching mechanism of excited-state drugs by oxygen was discussed.

引用

页码：2169 / 2173

页数：5

共 22 条

[1] TRIPLET ENERGY SURFACES OF ONE-WAY ISOMERIZING OLEFINS AS STUDIED BY SINGLET OXYGEN LUMINESCENCE TECHNIQUE [J].