SYNTHESIS OF A C-PHOSPHONATE DISACCHARIDE AS A POTENTIAL INHIBITOR OF PEPTIDOGLYCAN POLYMERIZATION BY TRANSGLYCOSYLASE

被引：39

作者：

QIAO, L ^{[1
]}

VEDERAS, JC ^{[1
]}

机构：

[1] UNIV ALBERTA,DEPT CHEM,EDMONTON T6G 2G2,ALBERTA,CANADA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 13期

关键词：

D O I：

10.1021/jo00065a004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A phosphonate disaccharide 4, having structural features of both peptidoglycan monomer 1 and the active portion 2 of moenomycin A, was synthesized as a potential antibiotic and inhibitor of transglycosylase, an enzyme responsible for formation of the polysaccharide backbone of bacterial peptidoglycan.

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页码：3480 / 3482

页数：3

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