SERIOUS OR FATAL COMPLICATIONS AFTER INADVERTENT ADMINISTRATION OF IONIC WATER-SOLUBLE CONTRAST-MEDIA IN MYELOGRAPHY

被引：25

作者：

ROSATI, G

DIPRIOLO, SL

TIRONE, P

机构：

来源：

EUROPEAN JOURNAL OF RADIOLOGY | 1992年 / 15卷 / 02期

关键词：

CONTRAST MEDIA; MYELOGRAPHY; COMPLICATION;

D O I：

10.1016/0720-048X(92)90131-R

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The consequences of the inadvertent administration, by the intrathecal route, of ionic contrast media instead of iopamidol in seven subjects are reported. The ionic compounds were diatrizoate, iodamide and ioxitalamate. The outcome was fatal in three out of seven subjects, and it depended on the type and the dose of the administered contrast agent. The serious or fatal reactions observed are a tragic confirmation of the predictive power of neurotoxicity data obtained in animal studies with various iodinated water-soluble compounds. The margin of safety, represented by the ratio of LD50 i.ce. in mice to clinical dose in humans, both normalized to bodyweight, appears to reliably reflect the risk of toxic reactions after intrathecal administration of iodinated contrast agents.

引用

页码：95 / 100

页数：6

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