ENANTIOSELECTIVE INHIBITION OF APOMORPHINE-INDUCED EMESIS IN THE FERRET BY THE NEUROKININ(1) RECEPTOR ANTAGONIST CP-99,994

被引：85

作者：

TATTERSALL, FD

RYCROFT, W

HILL, RG

HARGREAVES, RJ

机构：

[1] Merck, Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex CM20 2QR, Terlings Park

来源：

NEUROPHARMACOLOGY | 1994年 / 33卷 / 02期

关键词：

ANTIEMETIC; CP-99,994; FERRETS; APOMORPHINE-INDUCED EMESIS; NEUROKININ(1) RECEPTOR; VOMITING;

D O I：

10.1016/0028-3908(94)90018-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

These studies have examined the effects of the selective neurokinin, (NK1) receptor antagonist CP-99,994 on the retching and vomiting response to apomorphine. CP-99,994 (1-3 mg/kg i.p.) attenuated retching and vomiting induced by apomorphine (0.25 mg/kg s.c.) with complete inhibition of retching and vomiting at the 3 mg/kg dose. In contrast CP-100,263 (3 mg/kg i.p.), the enantiomer of CP-99,994 with 1000-fold lower affinity for the NK1 receptor, was without effect.

引用

页码：259 / 260

页数：2

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