SIMULTANEOUS LTP OF NON-NMDA-RECEPTER-MEDIATED AND LTD OF NMDA-RECEPTER-MEDIATED RESPONSES IN THE NUCLEUS-ACCUMBENS

被引:172
作者
KOMBIAN, SB
MALENKA, RC
机构
[1] UNIV CALIF SAN FRANCISCO,DEPT PSYCHIAT,LPPI,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL,SAN FRANCISCO,CA 94143
关键词
D O I
10.1038/368242a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
THE nucleus accumbens (NA), a ventral extension of the striatum, plays a role in several complex behaviour patterns(1) and also is a major site of action of drugs of abuse such as cocaine(1-3). Intrinsic NA cells are predominantly quiescent(4,5) and their activity depends on excitatory input from cortical and subcortical limbic afferents(6,7). Here we examine the mechanisms of synaptic plasticity at the synapse between prelimbic cortical afferents and cells in the core region of the NA(8-10). Manipulations that induce a Ca2+- dependent long-term potentiation (LTP) of non-NMDA (N-methyl-D-aspartate)-receptor-mediated responses also produce a simultaneous long-term depression (LTD) of NMDA-receptor-mediated responses. These results indicate that in a single cell the same change in postsynaptic Ca2+ concentration can have opposite effects on non-NMDA- and NMDA-receptor-mediated synaptic responses. This may be particularly important in the NA, where NMDA receptors are critical for mediating the behavioural actions of drugs of abuse(11-13).
引用
收藏
页码:242 / 246
页数:5
相关论文
共 30 条