SEPARATION OF DRUGS BY PACKED-COLUMN SUPERCRITICAL-FLUID CHROMATOGRAPHY .2. ANTIDEPRESSANTS

被引：35

作者：

BERGER, TA

WILSON, WH

机构：

[1] Hewlett Packard Company, Wilmington, Delaware, 19808

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1994年 / 83卷 / 03期

关键词：

D O I：

10.1002/jps.2600830305

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Antidepressants can be rapidly and efficiently separated by packed-column supercritical fluid chromatography with a tertiary mobile phase. Ten antidepressants were nearly baseline resolved in <6 min without programming. Calculated detection limits with a 5-mu L injection volume were as low as 88 ppb. The effects of temperature, pressure, and modifier concentration on retention and selectivity were studied. Changing modifier concentration caused significant changes in selectivity. Several relationships between solute structure and selectivity changes were noted.

引用

页码：287 / 290

页数：4

共 14 条

[1] EFFECT OF BASIC ADDITIVES ON PEAK SHAPES OF STRONG BASES SEPARATED BY PACKED-COLUMN SUPERCRITICAL FLUID CHROMATOGRAPHY
BERGER, TA
DEYE, JF
[J]. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1991, 29 (07) : 310 - 317
[2] SUPERCRITICAL FLUID CHROMATOGRAPHIC RETENTION OF ANILINES WITH PURE AND MODIFIED FLUIDS ON STANDARD AND DEACTIVATED COLUMNS
BERGER, TA
DEYE, JF
[J]. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1991, 29 (09) : 390 - 395
[3] BERGER TA, 1991, HRC-J HIGH RES CHROM, V14, P312
[4] BERGER TA, 1988, J CHROMATOGR SCI, V26, P131
[5] BERGER TA, J PHARM SCI
[6] DEWEERDT M, 1990, HRC-J HIGH RES CHROM, V13, P40
[7] GILPIN RK, 1991, ANAL CHEM, V63, pR130
[8] DRUG LEVEL MONITORING - ANTIDEPRESSANTS
GUPTA, RN
[J]. JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1992, 576 (02): : 183 - 211
[9] KHORASSANI MA, 1988, MODERN SUPERCRITICAL, pCH7
[10] KHORASSANI MA, 1988, J CHROMATOGR SCI, V26, P331

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