FORMATION AND AUTOCATALYTIC DESTRUCTION OF THE QUINONE METHIDE FROM REDUCTIVE CLEAVAGE OF MENOGARIL

被引：17

作者：

BOLDT, M ^{[1
]}

GAUDIANO, G ^{[1
]}

HADDADIN, MJ ^{[1
]}

KOCH, TH ^{[1
]}

机构：

[1] UNIV COLORADO,DEPT CHEM & BIOCHEM,BOULDER,CO 80309

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1988年 / 110卷 / 10期

关键词：

D O I：

10.1021/ja00218a070

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：3330 / 3332

页数：3

共 15 条

[1] A CHEMICAL PERSPECTIVE ON THE ANTHRACYCLINE ANTITUMOR ANTIBIOTICS [J].

ABDELLA, BRJ ;

FISHER, J .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1985, 64 :3-18

[2] SUBSTITUENT EFFECTS ON THE REDOX CHEMISTRY OF ANTHRACYCLINE ANTITUMOR DRUGS [J].

BOLDT, M ;

GAUDIANO, G ;

KOCH, TH .

JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (11) :2146-2153

[3] ELECTRON-TRANSFER CHEMISTRY OF THE MEROSTABILIZED 3,5,5-TRIMETHYL-2-MORPHOLINON-3-YL RADICAL [J].

BURNS, JM ;

WHARRY, DL ;

KOCH, TH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (04) :849-856

[4]

DODION P, 1985, CANCER RES, V45, P5352

[5]

EGORIN MJ, 1986, CANCER RES, V46, P1513

[6] ANTHRACYCLINE ANTIBIOTIC REDUCTION BY SPINACH FERREDOXIN NADP+ REDUCTASE AND FERREDOXIN [J].

FISHER, J ;

ABDELLA, BRJ ;

MCLANE, KE .

BIOCHEMISTRY, 1985, 24 (14) :3562-3571

[7] SPECTROSCOPIC AND KINETIC EVIDENCE FOR THE TAUTOMER OF 7-DEOXYALKLAVINONE AS AN INTERMEDIATE IN THE REDUCTIVE COUPLING OF ACLACINOMYCIN-A [J].

KLEYER, DL ;

GAUDIANO, G ;

KOCH, TH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (04) :1105-1109

[8]

KLEYER DL, 1984, J AM CHEM SOC, V106, P2380, DOI 10.1021/ja00320a027

[9] BIOACTIVATION AS A MODEL FOR DRUG DESIGN BIOREDUCTIVE ALKYLATION [J].

MOORE, HW .

SCIENCE, 1977, 197 (4303) :527-532

[10] NATURALLY-OCCURRING QUINONES AS POTENTIAL BIOREDUCTIVE ALKYLATING-AGENTS [J].

MOORE, HW ;

CZERNIAK, R .

MEDICINAL RESEARCH REVIEWS, 1981, 1 (03) :249-280

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