GLUCOSPHINGOLIPID SYNTHESIS IN THE CELLULAR SLIME-MOLD DICTYOSTELIUM-DISCOIDEUM

被引：5

作者：

CREAN, EV

ROSSOMANDO, EF

机构：

[1] Department of Oral Biology, University of Connecticut Health Center, Farmington

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1979年 / 196卷 / 01期

关键词：

D O I：

10.1016/0003-9861(79)90565-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transfer of glucose from UDP-[14C]glucose to endogenous acceptors has been examined using a particulate fraction prepared from Dictyostelium discoideum. In the presence of EDTA, the sole product is a 14C-labeled glucolipid with the chemical and chromatographic properties of a monoglucosylceramide containing a hydroxy fatty acid. While the reaction does not require a divalent cation, various cations stimulate or inhibit the transferase activity. Other nucleotide sugars have little or no effect on the reaction. Preliminary studies suggest that glycosphingolipid metabolism is developmentally regulated in D. discoideum. © 1979.

引用

页码：186 / 191

页数：6

共 25 条

[1] BIOSYNTHESIS OF GLYCOPROTEINS DURING DEVELOPMENT OF DICTYOSTELIUM-DISCOIDEUM - TRANSFER OF D-MANNOSE IN VEGETATIVE AND AGGREGATED CELLS [J].