IRON-DEFICIENCY PREVENTS LIVER TOXICITY OF 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN

被引：94

作者：

SWEENEY, GD

JONES, KG

COLE, FM

BASFORD, D

KRESTYNSKI, F

机构：

[1] MCMASTER UNIV, DEPT BIOCHEM, HAMILTON L8S 4J9, ONTARIO, CANADA

[2] MCMASTER UNIV, DEPT PATHOL, HAMILTON L8S 4J9, ONTARIO, CANADA

来源：

SCIENCE | 1979年 / 204卷 / 4390期

关键词：

D O I：

10.1126/science.432648

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatocellular damage and porphyria in C57B1/6J mice, among a wide range of toxic effects. We compared the effect of TCDD toxicity in iron-deficient mice with that in mice receiving a normal diet. Porphyria did not develop in the iron-deficient animals, and these animals were also protected from hepatocellular damage and certain other toxic effects of TCDD.

引用

页码：332 / 335

页数：4

共 23 条

[1] INDUSTRIALLY ACQUIRED PORPHYRIA [J].

BLEIBERG, J ;

BRODKIN, R ;

WALLEN, M ;

APPLEBAUM, IL .

ARCHIVES OF DERMATOLOGY, 1964, 89 (06) :793-+

[2]

BURKE MD, 1974, DRUG METAB DISPOS, V2, P583

[3]

Drabkin DL, 1935, J BIOL CHEM, V112, P51

[4] EFFECT OF PORPHYROGENIC COMPOUND, HEXACHLOROBENZENE, ON ACTIVITY OF HEPATIC UROPORPHYRINOGEN DECARBOXYLASE IN RAT [J].

ELDER, GH ;

EVANS, JO ;

MATLIN, SA .

CLINICAL SCIENCE AND MOLECULAR MEDICINE, 1976, 51 (01) :71-80

[5]

GOLDSTEIN JA, 1973, RES COMMUN CHEM PATH, V6, P919

[6]

GUPTA B N, 1973, Environmental Health Perspectives, V5, P125

[7]

HARRIS M W, 1973, Environmental Health Perspectives, V5, P101, DOI 10.2307/3428118

[8]

HENRY RP, 1964, CLIN CHEM, P387

[9]

IPPEN H, 1962, Panminerva Med, V4, P381

[10] MEASUREMENT OF URINE PORPHYRINS AND PORPHYRINOGENS [J].

JONES, KG ;

SWEENEY, GD .

BIOCHEMICAL MEDICINE, 1976, 15 (03) :223-232

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