TITANOCENE DICHLORIDE - 1ST METALLOCENE WITH CANCEROSTATIC ACTIVITY

被引：253

作者：

KOPF, H ^{[1
]}

KOPFMAIER, P ^{[1
]}

机构：

[1] FREE UNIV BERLIN,INST ANAT,D-1000 BERLIN 33,FED REP GER

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1979年 / 18卷 / 06期

关键词：

D O I：

10.1002/anie.197904771

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The cancerostatic activity of metal complexes can be tested on mice by injection of tumor cells and, 24 h later, the substance to be investigated. Compound 1, selected partly because of its structural similarity to the antitumor agent 2, exhibited a cure rate of over 80% in the therapeutic range. (Figure Presented.) Copyright © 1979 by Verlag Chemie, GmbH, Germany

引用

页码：477 / 478

页数：2

共 9 条

[1] HYDROXO-BRIDGED PLATINUM(II) COMPLEXES .1. DI-MU-HYDROXO-BIS[DIAMMINEPLATINUM(II)] NITRATE, [(NH3)2PT(OH)2PT(NH3)2](NO3)2 CRYSTALLINE-STRUCTURE AND VIBRATIONAL-SPECTRA
FAGGIANI, R
LIPPERT, B
LOCK, CJL
ROSENBERG, B
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (03) : 777 - 781
[2] GOLDMANN R, 1978, THESIS TU BERLIN
[3] ORGANOMETAL POLYCHALCOGENIDE CHELATES .I. FORMATION OF TITANIUM DIOXIDE-CYCLOHEXA-SULFUR FROM POLYSULFIDES
KOPF, H
BLOCK, B
[J]. CHEMISCHE BERICHTE-RECUEIL, 1969, 102 (05): : 1504 - &
[4] KOPF H, UNPUBLISHED
[5] PLATINUM COMPLEXES - NEW CLASS OF ANTINEOPLASTIC AGENTS
LEH, FKV
WOLF, W
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1976, 65 (03) : 315 - 328
[6] INHIBITION OF CELL DIVISION IN ESCHERICHIA COLI BY ELECTROLYSIS PRODUCTS FROM A PLATINUM ELECTRODE
ROSENBERG, B
VANCAMP, L
KRIGAS, T
[J]. NATURE, 1965, 205 (4972) : 698 - +
[7] ORGANOMETALLIC COMPLEX WITH COORDINATIVELY BOUND WATER - ([ETA-C5H5)2TI(H2O)]2O]S2O6
THEWALT, U
SCHLEUSSNER, G
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1978, 17 (07): : 531 - 531
[8] THEWALT U, 1978, ANGEW CHEM, V90, P559
[9] BIS-CYCLOPENTADIENYL COMPOUNDS OF TI, ZR, V, NB AND TA
WILKINSON, G
BIRMINGHAM, JM
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1954, 76 (17) : 4281 - 4284

← 1 →