PEAK TRACKING AND SUBSEQUENT CHOICE OF OPTIMIZATION PARAMETERS FOR THE SEPARATION OF A MIXTURE OF LOCAL-ANESTHETICS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：12

作者：

STRASTERS, JK ^{[1
]}

COOLSAET, F ^{[1
]}

BARTHA, A ^{[1
]}

BILLIET, HAH ^{[1
]}

DEGALAN, L ^{[1
]}

机构：

[1] DELFT UNIV TECHNOL,DEPT ANALYT CHEM,DE VRIES VAN HEYSTPLANTSOEN 2,2628 RZ DELFT,NETHERLANDS

来源：

JOURNAL OF CHROMATOGRAPHY | 1990年 / 499卷

关键词：

D O I：

10.1016/S0021-9673(00)96997-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A peak tracking strategy based on multivariate analysis of multiwavelength spectral data was applied to four chromatograms of a mixture of eight local anaesthetics and extended to cope with coelution of components having identical spectral characteristics. The resulting characterization of the retention behaviour of the individual components was used to select a suitable parameter space for the subsequent improvement of the observed separation. © 1990.

引用

页码：523 / 540

页数：18

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