SYNTHESIS AND SCREENING FOR ANTI-BACTERIAL, ANTI-CANCER, ANTI-FUNGICIDAL AND ANTI-VIRAL ACTIVITIES OF SOME COMPLEXES OF PALLADIUM AND NICKEL

Several complexes of palladium and nickel have been synthesized and subjected to a variety of in vitro/in vivo screens. Of the complexes submitted the most positive antibacterial was (πC3H5PdCl)2, antrivirals were cisPd(NH3)2Cl2 and (NH4)2PdCl4, anticancers were cis and transPd(NH3)2Cl2, cisPd(NH3)2Cl4, Na2PdCl6, (NH4)2PdCl4, ethylenediamineH2·PdCl4, Pd(NH3)4·PdCl4, (πC3H5PdCl)2, Pd(cyclopentylamine)2Cl2, Pd(cyclohexylamine)2Cl2, and some palladium asparaginate complexes, and the most toxic complexes were (πC3H5PdCl)2 and Ni(py)4(NCO)2. There appears to be different structural criteria which are necessary for active anticancer Pd complexes as compared to active Pt complexes. The advantages of introducing Pd into drugs are discussed. © 1979.