EXPRESSION OF RET PROTOONCOGENE IN HUMAN NEUROBLASTOMAS

被引：46

作者：

NAGAO, M

ISHIZAKA, Y

NAKAGAWARA, A

KOHNO, K

KUWANO, M

TAHIRA, T

ITOH, F

IKEDA, I

SUGIMURA, T

机构：

[1] KYUSHU UNIV,FAC MED,DEPT PEDIAT SURG,HIGASHI KU,FUKUOKA 812,JAPAN

[2] OITA MED SCH,DEPT BIOCHEM,HAZAMA,OITA 87956,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1990年 / 81卷 / 04期

关键词：

Clinical stage; Expression of ret proto‐oncogene; Neuroblastoma; N‐myc amplification;

D O I：

10.1111/j.1349-7006.1990.tb02566.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined the expression of ret proto‐oncogene (proto‐ret) in surgically resected human neuroblastomas. Slot blot RNA hybridization revealed that all 29 neuroblastomas examined expressed the proto‐ret, the relative intensity of the hybridization ranging from 1 to 48. No correlation was found between the level of expression of proto‐ret and the clinical stage. The level of expression was also not correlated with N‐myc amplification, the patient's age or the histological type of the tumor. Based on the previous finding that proto‐ret expression is very rarely detected in tumor cell lines other than those of neuroblastoma, proto‐ret expression was suggested to be a characteristic of neuroblastomas, and possibly to be involved in the genesis of neuroblastomas. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：309 / 312

页数：4

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