SEQUENCE OF THE FUSION PROTEIN GENE OF HUMAN PARAINFLUENZA TYPE-2 VIRUS AND ITS 3' INTERGENIC REGION - LACK OF SMALL HYDROPHOBIC (SH) GENE

被引:32
作者
KAWANO, M
BANDO, H
OHGIMOTO, S
KONDO, K
TSURUDOME, M
NISHIO, M
ITO, Y
机构
[1] MIE UNIV, SCH MED, DEPT MICROBIOL, 2-174 EDOBASHI, TSU, MIE 514, JAPAN
[2] FUJIKURA KASEI CO LTD, FUJIKURA RES CTR, ITABASHI KU, TOKYO, JAPAN
关键词
D O I
10.1016/0042-6822(90)90406-H
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
cDNA clones representing the fusion (F) gene of human parainfluenza virus type 2 (PIV-2) were isolated from cDNA libraries constructed from virus-specific mRNA and genomic RNA, and the complete nucleotide sequence of the F gene was determined. The F gene is 1854 nucleotides long and encodes one long open reading frame of 551 amino acids. The cleavage site for activation of the precursor Fo protein is ThrArgGlnLysArg. The F gene of PIV-2 is most closely related to those of simian virus 5 (SV5) and mumps virus (MuV). Interestingly, although the HN glycoprotein of PIV-2 shows no relatedness to the HA glycoprotein of measles virus (MV), a distinct homology is found in the F proteins of PIV-2 and MV. As concerns F proteins, paramyxoviruses can be divided intt two subgroups; that is, PIV-2, SV5, and MuV belong to one group, and HPIV-1, SV, and PIV-3 belong to the other group. Newcastle disease virus (NDV) and MV are intermediate. Coding regions for small hydrophobic (SH) proteins have been found between the HN and F genes of SV5 and MuV, which are the viruses most closely related to PIV-2. However, such a gene could not be detected in two different strains of PIV-2. © 1990.
引用
收藏
页码:289 / 292
页数:4
相关论文
共 30 条
[1]   EVIDENCE THAT THE FUSION PROTEIN OF RESPIRATORY SYNCYTIAL VIRUS EXISTS AS A DIMER IN ITS NATIVE FORM [J].
ARUMUGHAM, RG ;
HILDRETH, SW ;
PARADISO, PR .
ARCHIVES OF VIROLOGY, 1989, 106 (3-4) :327-334
[2]   SEQUENCE DETERMINATION OF THE SENDAI VIRUS FUSION PROTEIN GENE [J].
BLUMBERG, BM ;
GIORGI, C ;
ROSE, K ;
KOLAKOFSKY, D .
JOURNAL OF GENERAL VIROLOGY, 1985, 66 (FEB) :317-331
[3]   LEUCINE ZIPPER MOTIF EXTENDS [J].
BUCKLAND, R ;
WILD, F .
NATURE, 1989, 338 (6216) :547-547
[4]   NUCLEOTIDE-SEQUENCE OF THE GENE ENCODING THE FUSION GLYCOPROTEIN OF NEWCASTLE-DISEASE VIRUS [J].
CHAMBERS, P ;
MILLAR, NS ;
EMMERSON, PT .
JOURNAL OF GENERAL VIROLOGY, 1986, 67 :2685-2694
[5]   NUCLEOTIDE-SEQUENCE OF THE CODING AND FLANKING REGIONS OF THE HUMAN PARA-INFLUENZA VIRUS TYPE-3 FUSION GLYCOPROTEIN GENE [J].
COTE, MJ ;
STOREY, DG ;
KANG, CY ;
DIMOCK, K .
JOURNAL OF GENERAL VIROLOGY, 1987, 68 :1003-1010
[6]   MOLECULAR-CLONING AND CHARACTERIZATION OF 6 GENES, DETERMINATION OF GENE ORDER AND INTERGENIC SEQUENCES AND LEADER SEQUENCE OF MUMPS-VIRUS [J].
ELANGO, N ;
VARSANYI, TM ;
KOVAMEES, J ;
NORRBY, E .
JOURNAL OF GENERAL VIROLOGY, 1988, 69 :2893-2900
[7]   MESSENGER-RNA SEQUENCE AND DEDUCED AMINO-ACID SEQUENCE OF THE MUMPS-VIRUS SMALL HYDROPHOBIC PROTEIN GENE [J].
ELANGO, N ;
KOVAMEES, J ;
VARSANYI, TM ;
NORRBY, E .
JOURNAL OF VIROLOGY, 1989, 63 (03) :1413-1415
[8]   NUCLEOTIDE-SEQUENCE OF THE MATRIX, FUSION AND PUTATIVE SH PROTEIN GENES OF MUMPS-VIRUS AND THEIR DEDUCED AMINO-ACID SEQUENCES [J].
ELLIOTT, GD ;
AFZAL, MA ;
MARTIN, SJ ;
RIMA, BK .
VIRUS RESEARCH, 1989, 12 (01) :61-75
[9]   A SIMPLE AND VERY EFFICIENT METHOD FOR GENERATING CDNA LIBRARIES [J].
GUBLER, U ;
HOFFMAN, BJ .
GENE, 1983, 25 (2-3) :263-269
[10]   IDENTIFICATION AND PREDICTED SEQUENCE OF A PREVIOUSLY UNRECOGNIZED SMALL HYDROPHOBIC PROTEIN, SH, OF THE PARAMYXOVIRUS SIMIAN VIRUS-5 [J].
HIEBERT, SW ;
PATERSON, RG ;
LAMB, RA .
JOURNAL OF VIROLOGY, 1985, 55 (03) :744-751