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SEQUENCE OF THE FUSION PROTEIN GENE OF HUMAN PARAINFLUENZA TYPE-2 VIRUS AND ITS 3' INTERGENIC REGION - LACK OF SMALL HYDROPHOBIC (SH) GENE
被引:32
作者:
KAWANO, M
BANDO, H
OHGIMOTO, S
KONDO, K
TSURUDOME, M
NISHIO, M
ITO, Y
机构:
[1] MIE UNIV, SCH MED, DEPT MICROBIOL, 2-174 EDOBASHI, TSU, MIE 514, JAPAN
[2] FUJIKURA KASEI CO LTD, FUJIKURA RES CTR, ITABASHI KU, TOKYO, JAPAN
来源:
关键词:
D O I:
10.1016/0042-6822(90)90406-H
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
cDNA clones representing the fusion (F) gene of human parainfluenza virus type 2 (PIV-2) were isolated from cDNA libraries constructed from virus-specific mRNA and genomic RNA, and the complete nucleotide sequence of the F gene was determined. The F gene is 1854 nucleotides long and encodes one long open reading frame of 551 amino acids. The cleavage site for activation of the precursor Fo protein is ThrArgGlnLysArg. The F gene of PIV-2 is most closely related to those of simian virus 5 (SV5) and mumps virus (MuV). Interestingly, although the HN glycoprotein of PIV-2 shows no relatedness to the HA glycoprotein of measles virus (MV), a distinct homology is found in the F proteins of PIV-2 and MV. As concerns F proteins, paramyxoviruses can be divided intt two subgroups; that is, PIV-2, SV5, and MuV belong to one group, and HPIV-1, SV, and PIV-3 belong to the other group. Newcastle disease virus (NDV) and MV are intermediate. Coding regions for small hydrophobic (SH) proteins have been found between the HN and F genes of SV5 and MuV, which are the viruses most closely related to PIV-2. However, such a gene could not be detected in two different strains of PIV-2. © 1990.
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页码:289 / 292
页数:4
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