MUTAGENICITY OF RESIN ACIDS IDENTIFIED IN PULP AND PAPER-MILL EFFLUENTS USING THE SALMONELLA-MAMMALIAN-MICROSOME ASSAY

被引：31

作者：

NESTMANN, ER

LEE, EGH

MUELLER, JC

DOUGLAS, GR

机构：

[1] HLTH & WELF CANADA,DIV ENVIRONM & OCCUPAT TOXICOL,MUTAGENESIS SECT,OTTAWA K1A 0L2,ONTARIO,CANADA

[2] DIV APPL BIOL,VANCOUVER,BC,CANADA

来源：

ENVIRONMENTAL MUTAGENESIS | 1979年 / 1卷 / 04期

关键词：

effluent; mutagenicity; pulp mill; resin acids; Salmonella;

D O I：

10.1002/em.2860010408

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Ten resin acids which have been identified as constituents of pulp and paper mill effluents have been examined for potential mutagenicity in the Salmonella/mammalian‐microsome assay. Only neoabietic acid has been found to be mutagenic. Neoabietic acid showed dose‐related increases in mutagenicity in strains TA1535, TA100, TA1538, and TA98, but not in strain TA1537. Metabolic activation with a preparation of Aroclor 1254‐induced liver homogenate (S9) slightly reduced the mutagenic responses. Negative responses were found for abietic acid, dehydroabietic acid, levopimaric acid, 7‐oxodehydroabietic acid, monochlorodehydroabietic acid, dichlorodehydroabietic acid, pimaric acid, isopimaric acid, and sandaracopimaric acid. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：361 / 369

页数：9

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