T(12,22)(Q13,Q13) AND TRISOMY-8 ARE NONRANDOM ABERRATIONS IN CLEAR-CELL SARCOMA

被引：35

作者：

RODRIGUEZ, E

SREEKANTAIAH, C

REUTER, VE

MOTZER, RJ

CHAGANTI, RSK

机构：

[1] MEM HOSP CANC & ALLIED DIS,MEM SLOAN KETTERING CANC CTR,DEPT PATHOL,NEW YORK,NY 10021

[2] MEM HOSP CANC & ALLIED DIS,MEM SLOAN KETTERING CANC CTR,DEPT MED,DIV SOLID TUMOR ONCOL,NEW YORK,NY 10021

来源：

CANCER GENETICS AND CYTOGENETICS | 1992年 / 64卷 / 02期

关键词：

D O I：

10.1016/0165-4608(92)90338-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a case of clear-cell sarcoma with a t(12;22)(q13;q13) and multiple copies of chromosome 8 in addition to other abnormalities. An identical or similar translocation has previously been reported in this type of tumor, suggesting that the t(12;22) is a primary cytogenetic change in the pathogenesis of a subset of clear-cell sarcomas. In addition, the presence of extra copies of chromosome 8, commonly noted in our case and others, suggests that it represents a nonrandom secondary change in these tumors.

引用

页码：107 / 110

页数：4

共 30 条

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