CYTOKINES STIMULATE LIPOLYSIS AND DECREASE LIPOPROTEIN-LIPASE ACTIVITY IN CULTURED FAT-CELLS BY A PROSTAGLANDIN INDEPENDENT MECHANISM

被引：63

作者：

HARDARDOTTIR, I ^{[1
]}

DOERRLER, W ^{[1
]}

FEINGOLD, KR ^{[1
]}

GRUNFELD, C ^{[1
]}

机构：

[1] VET ADM MED CTR, MED SERV, METAB SECT, SAN FRANCISCO, CA 94121 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)80798-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We previously showed that indomethacin blocked the effect of tumor necrosis factor (TNF) and other cytokines on lipolysis. We now show that TNF stimulates prostaglandin (PG) production, enhances lipolysis and decreases lipoprotein lipase (LPL) activity in 3T3-F442A adipocytes and indomethacin blocks these activities, suggesting that the actions of TNF are mediated by PG's. However, exogenous PGE2 at the levels induced by TNF is not sufficient to affect lipolysis or LPL activity and low doses of indomethacin and flurbiprofen block PG production without affecting TNF's action. Interleukin-1 and interferon-α and γ induce lipolysis and decrease LPL activity but do not stimulate much PG production. These results demonstrate that cytokines enhance lipolysis and decrease LPL activity in 3T3 adipocytes by a PG independent mechanism. © 1992 Academic Press, Inc.

引用

页码：237 / 243

页数：7

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