REGULATION OF DYNEIN-DRIVEN MICROTUBULE SLIDING BY THE RADIAL SPOKES IN FLAGELLA

被引:150
作者
SMITH, EF
SALE, WS
机构
[1] Department of Anatomy and Cell Biology, Emory University School of Medicine, Atlanta
关键词
D O I
10.1126/science.1387971
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The regulation of microtubule sliding in flagellar axonemes was studied with the use of Chlamydomonas mutants and in vitro assays. Microtubule sliding velocities were diminished in axonemes from mutant cells missing radial spoke structures but could be restored upon reconstitution with dynein from axonemes with wild-type radial spokes. These experiments demonstrate that the radial spokes activate dynein's microtubule sliding activity.
引用
收藏
页码:1557 / 1559
页数:3
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