RELATIVE IMPORTANCE OF RISK-FACTORS IN BLADDER CARCINOGENESIS - SOME NEW RESULTS ABOUT MEDITERRANEAN HABITS

被引：35

作者：

MOMAS, I

DAURES, JP

FESTY, B

BONTOUX, J

GREMY, F

机构：

[1] Laboratoire d'Hygiène et de Santé Publique, Faculté des Sciences Pharmaceutiques et Biologiques, Paris Cédex 06, 75 270

[2] Department of Medical Information, Hôpital Lapeyronie, Montpellier

[3] the Department of Medical Information, Hopital Caremeau, Nimes

[4] the Department 'Sciences de l'Environnement et Santé Publique', Faculté de Pharmacie, Montpellier

来源：

CANCER CAUSES & CONTROL | 1994年 / 5卷 / 04期

关键词：

ALCOHOL; BETA-CAROTENE; BLADDER CANCER; CASE-CONTROL STUDY; COFFEE; FRANCE; MALES; SPICES; MEDITERRANEAN HABITS; SMOKING;

D O I：

10.1007/BF01804983

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the Mediterranean region of France where bladder cancer mortality and incidence are high, a case-control study with 219 male incident cases and 794 randomized, male population-controls was carried out in 1987-89 to investigate bladder cancer risk factors and more specifically, regional factors. A stepwise logistic regression was applied to the data. This investigation confirms the role of tobacco and of certain occupational exposures in bladder carcinogenesis. There was a significant dose-response relationship with lifelong coffee drinking and alcohol consumption; however the risk estimates were only significantly elevated for the heaviest drinkers. The intake of saccharin was not associated with risk of bladder cancer. Infrequent consumption of carrots, spinach, and marrows conferred an increased risk, suggesting a protective effect of vitamin A. Finally, this investigation results in some new hypotheses. The study of residences and birthplaces has revealed a lower risk for those who have lived in a non-Mediterranean area and a higher risk for those born in a Mediterranean area. These features might be explained by some Mediterranean dietary habits, such as a high consumption of spices (odds ratio = 3.64, 95 percent confidence interval = 2.21-5.98).

引用

页码：326 / 332

页数：7

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