RISK OF BREAST-CANCER IN RELATION TO BLOOD-LIPIDS - A PROSPECTIVE-STUDY OF 31,209 NORWEGIAN WOMEN

被引：73

作者：

GAARD, M

TRETLI, S

URDAL, P

机构：

[1] Institute for Epidemiological Cancer Research, Cancer Registry of Norway, Oslo, 0310, Montebello

[2] Department of Clinical Chemistry, Ulleval Hospital, Oslo

来源：

CANCER CAUSES & CONTROL | 1994年 / 5卷 / 06期

关键词：

BREAST CANCER; CHOLESTEROL; HDL-CHOLESTEROL; NORWAY; SERUM LIPIDS; TRIGLYCERIDES;

D O I：

10.1007/BF01831377

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

In this prospective study, the relationship between blood lipids and breast cancer risk was examined. Between 1977 and 1983, 31,209 Norwegian women, 20 to 54 years of age, attended a health screening carried out by the Norwegian National Health Screening Services. The screening consisted of a questionnaire, anthropometric measurements, and nonfasting blood drawn for analysis of total serum cholesterol (TC), triglyceride (TG), and high density lipoprotein (HDL) cholesterol. Low density lipoprotein (LDL) cholesterol was calculated by the Friedewald's formula. During the seven to 13 years of follow-up, 302 breast cancer cases were identified by linkage to the Norwegian Cancer Registry. After adjustment for some of the known risk factors of breast cancer, the relative risk of women in the highest quartile of TC compared with women in the lowest quartile was 0.87 (95 percent confidence interval [CI] = 0.61-1.23). The corresponding relative risks and CIs were 0.82 (CI = 0.58-1.16) for TG, 1.02 (CI = 0.73-1.42) for HDL, and 0.93 (CI = 0.67-1.29) for LDL. No association between breast cancer risk and blood lipids was found in the total population, nor when the data were divided into those diagnosed before or after the age of 50 as a dividing line between pre- and postmenopausal diagnosis.

引用

页码：501 / 509

页数：9

共 45 条

[1]

Dunn J.E., Breast cancer among American Japanese in the San Francisco bay area, NCI Monogr, 47, pp. 157-60, (1975)

[2]

Buell P., Changing incidence of breast cancer in Japanese American women, JNCI, 51, pp. 1479-83, (1973)

[3]

Artrong B., Doll R., Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices, Int J Cancer, 15, pp. 617-31, (1975)

[4]

Drasar B.S., Irving D., Environmental factors and cancer of the colon and breast, Br J Cancer, 27, pp. 167-72, (1973)

[5]

Gaskill S.P., Mcguire W.L., Osborne C.K., Stern M.P., Breast cancer mortality and diet in the United States, Cancer Res, 39, pp. 3628-37, (1979)

[6]

Metabolic epidemiology of plasma cholesterol. Mechanisms of varition of plasma cholesterol within populations and between populations, Lancet, 2, pp. 991-5, (1986)

[7]

Keys A., Seven Countries: A Multivariate Analysis of Death and Coronary Heart Disease, (1980)

[8]

Stallones R.A., Ischemic heart disease and lipids in blood and diet, Ann Rev Nutr, 3, pp. 155-85, (1983)

[9]

Stamler J., Population studies, Nutrition, Lipids and Coronary Heart Disease: A Global View. Nutrition in Health and Disease, Vol 1, pp. 25-88, (1979)

[10]

Shekelle R.B., Stamler J., Paul O., Shyrock A.M., Liu S., Lepper M., Dietary lipids and serum cholesterol level: change in diet confounds the cross-sectional association, Am J Epidemiol, 115, pp. 506-14, (1981)

← 1 2 3 4 5 →