CATALYSIS OF CARBAMATE HYDROLYSIS BY AN ANTIBODY

被引：13

作者：

VANVRANKEN, DL ^{[1
]}

PANOMITROS, D ^{[1
]}

SCHULTZ, PG ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,DEPT CHEM,BERKELEY,CA 94720

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 23期

关键词：

D O I：

10.1016/S0040-4039(00)76689-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We demonstrate that antibodies generated to a nitrophenylphosphonate hapten are able to catalyze hydrolysis of the corresponding ester 4 and carbamate 2, but not the alternative carbamate 5 or amide 6.

引用

页码：3873 / 3876

页数：4

共 10 条

[1] CATALYSIS OF A STEREOSPECIFIC BIMOLECULAR AMIDE SYNTHESIS BY AN ANTIBODY [J].

BENKOVIC, SJ ;

NAPPER, AD ;

LERNER, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (15) :5355-5358

[2] CATALYTIC ANTIBODIES FOR THE HYDROLYSIS OF UNACTIVATED PEPTIDES [J].

BLACKBURN, GM ;

DENG, SX .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1993, 21 (04) :1102-1107

[3] LINEAR EQUATION THAT DESCRIBES STEADY-STATE KINETICS OF ENZYMES AND SUBCELLULAR PARTICLES INTERACTING WITH TIGHTLY BOUND INHIBITORS [J].

HENDERSON, PJ .

BIOCHEMICAL JOURNAL, 1972, 127 (02) :321-+

[4] CONTROLLING CHEMICAL-REACTIVITY WITH ANTIBODIES [J].

HSIEH, LC ;

YONKOVICH, S ;

KOCHERSPERGER, L ;

SCHULTZ, PG .

SCIENCE, 1993, 260 (5106) :337-339

[5]

JACKSON DY, 1991, THESIS U CALIFORNIA

[6] CATALYTIC ANTIBODIES [J].

JACOBS, J ;

SCHULTZ, PG ;

SUGASAWARA, R ;

POWELL, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (07) :2174-2176

[7] INDUCTION OF AN ANTIBODY THAT CATALYZES THE HYDROLYSIS OF AN AMIDE BOND [J].

JANDA, KD ;

SCHLOEDER, D ;

BENKOVIC, SJ ;

LERNER, RA .

SCIENCE, 1988, 241 (4870) :1188-1191

[8]

LEE DG, 1978, SYNTHESIS-STUTTGART, P462

[9] CATALYSIS OF CARBAMATE HYDROLYSIS BY VANCOMYCIN AND SEMISYNTHETIC DERIVATIVES [J].

SHI, Z ;

GRIFFIN, JH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (15) :6482-6486

[10] A NEW STRATEGY FOR THE GENERATION OF CATALYTIC ANTIBODIES [J].

SHOKAT, KM ;

LEUMANN, CJ ;

SUGASAWARA, R ;

SCHULTZ, PG .

NATURE, 1989, 338 (6212) :269-271

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