DIFFERENTIAL EXPRESSION OF APOLIPOPROTEIN-D AND PROSTATE-SPECIFIC ANTIGEN IN BENIGN AND MALIGNANT PROSTATE TISSUES

被引：35

作者：

ASPINALL, JO ^{[1
]}

BENTEL, JM ^{[1
]}

HORSFALL, DJ ^{[1
]}

HAAGENSEN, DE ^{[1
]}

MARSHALL, VR ^{[1
]}

TILLEY, WD ^{[1
]}

机构：

[1] FLINDERS UNIV S AUSTRALIA, SCH MED, DEPT SURG, BEDFORD PK, SA 5042, AUSTRALIA

来源：

JOURNAL OF UROLOGY | 1995年 / 154卷 / 02期

关键词：

IMMUNOHISTOCHEMISTRY; APOLIPOPROTEINS; PROSTATE SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; IMAGE PROCESSING; COMPUTER-ASSISTED;

D O I：

10.1016/S0022-5347(01)67123-4

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: To investigate Apolipoprotein-D (Apo-D) and prostate specific antigen (PSA) immunohistochemical staining of nonmalignant and malignant human prostate tissues. Materials and Methods: Apolipoprotein-D and PSA immunoreactivity were evaluated by video image analysis in nonmalignant prostates and in 30 stage D-2 prostate cancers. Results: Apolipoprotein-D was detected in all 30 tumors, and the level of staining was elevated in comparison to age-matched nonmalignant prostates (p <0.05). In contrast, the level of PSA staining in tumors was less than that detected in nonmalignant prostates. Conclusions: Apolipoprotein-D is expressed in normal human prostate. Elevated Apo-D staining is associated with advanced prostate cancer.

引用

页码：622 / 628

页数：7

共 24 条

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