INCORPORATION OF A PHOSPHONIUM ANALOG OF CHOLINE INTO THE RAT-BRAIN AS MEASURED BY MAGNETIC-RESONANCE SPECTROSCOPY

被引：5

作者：

JIMENEZ, JV ^{[1
]}

RICHARDS, TL ^{[1
]}

HEIDE, AC ^{[1
]}

GRIERSON, JR ^{[1
]}

SHANKLAND, EG ^{[1
]}

机构：

[1] UNIV WASHINGTON,DEPT RADIOL,SEATTLE,WA 98195

来源：

MAGNETIC RESONANCE IN MEDICINE | 1995年 / 33卷 / 03期

关键词：

CHOLINE; NMR; BRAIN; ANALOG;

D O I：

10.1002/mrm.1910330302

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A clear understanding of choline metabolism is important in our goal to modify demyelination and remyelination in multiple sclerosis. To develop a technique capable of measuring metabolic changes in the brain, we have studied the incorporation of a phosphonium analogue of choline (P-choline) in tissue extracts of rats. After feeding adult rats a choline-deficient diet supplemented with P-choline, the analogue was not detectable by in vivo volume-localized H-1 spectroscopy. However, in vitro P-31 measurements of brain extracts revealed an 11% incorporation of P-choline into phosphatidylcholine. We report that P-choline incorporates preferentially into the lipid pool over the lipid precursor pool and we provide evidence that the choline peak resolved by in vivo H-1 spectroscopy is only composed of small molecular weight choline-containing compounds.

引用

页码：285 / 292

页数：8

共 20 条

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[2]

Alvord Ellsworth C. Jr., 1992, P849

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