EFFECT OF ANTIHYPERTENSIVE TREATMENT ON THE INCREASED BETA(2)-ADRENOCEPTOR DENSITY IN PATIENTS WITH ESSENTIAL-HYPERTENSION

被引：10

作者：

BONO, M ^{[1
]}

CASES, A ^{[1
]}

CALLS, J ^{[1
]}

GAYA, J ^{[1
]}

JIMENEZ, W ^{[1
]}

CARRETERO, J ^{[1
]}

RIVERA, F ^{[1
]}

REVERT, L ^{[1
]}

机构：

[1] HOSP CLIN BARCELONA,SERV NEFROL,E-08036 BARCELONA,SPAIN

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1995年 / 8卷 / 05期

关键词：

BETA(2)-ADRENOCEPTORS; EPINEPHRINE; CGP12177; ESSENTIAL HYPERTENSION; BISOPROLOL;

D O I：

10.1016/0895-7061(95)00023-I

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The effect of different antihypertensive drugs on the increased surface beta(2)-adrenoceptor density in essential hypertension was evaluated to elucidate whether the possible effect of the treatment on these receptors was secondary to blood pressure decreases or a specific effect of the drugs. Thirty-nine untreated essential hypertensive patients and 28 normotensive control subjects were studied in basal conditions. Hypertensive patients were randomly assigned to three treatment groups: bisoprolol (10 mg/day, n = 15), enalapril (20 mg/day, n = 12), and verapamil SR (240 mg/day, n = 12), and were studied before and after 1 month of treatment. Plasma catecholamines were determined by a radioenzymatic assay. Surface beta(2)-adrenoceptors were measured in intact lymphocytes by radioligand binding assay using the hydrophilic ligand [H-3]-CGP12177. beta(2)-adrenoceptor density was increased in hypertensive patients (P < .01). After treatment, mean blood pressure decreased similarly in the three groups, while plasma catecholamines showed no significant changes in any group. beta(2)-adrenoceptor number decreased only in bisoprolol-treated patients (P < .05). Mean blood pressure decreases correlated with beta(2)-adrenoceptor decrements only in bisoprolol-treated patients (r = 0.65, P < .05). beta(2)-adrenoceptor density correlated with plasma epinephrine levels in the control group (r = -0.50, P < .01), but not in hypertensive patients before treatment. This correlation was also observed in hypertensive patients treated with bisoprolol (r -0.52, P < .05), but not in those treated with verapamil or enalapril. Our results suggest that bisoprolol treatment reduces the increased surface beta(2)-adrenoceptor density and restores its regulation by epinephrine in essential hypertension. This effect seems to be specific to beta-blockers, as these changes can be ascribed to neither blood pressure decreases nor to changes in plasma catecholamine levels.

引用

页码：487 / 493

页数：7

共 25 条

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