CHEMOENZYMATIC SYNTHESIS OF A LIPID-LINKED CORE TRISACCHARIDE OF N-LINKED GLYCOPROTEINS

被引：27

作者：

FLITSCH, SL ^{[1
]}

PINCHES, HL ^{[1
]}

TAYLOR, JP ^{[1
]}

TURNER, NJ ^{[1
]}

机构：

[1] UNIV EXETER, DEPT CHEM, EXETER EX4 4RJ, DEVON, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 16期

关键词：

D O I：

10.1039/p19920002087

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel analogues of the mannosyl transferase acceptor substrate (GlcNAc)2-P(i)-P(i)-dolichyl 2 have been prepared in which dolichyl is replaced by phytanyl, 4, and lauryl, 5; both compounds 4 and 5 were synthesized using readily available chitin as the disaccharide precursor. Compound 4 acts as an efficient acceptor substrate for mannosyl transferases from porcine liver and Saccharomyces cerevisiae.

引用

页码：2087 / 2093

页数：7

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