AN ENZYMATIC ENANTIOSELECTIVE ROUTE TO METHYL CARBOXYLATE 2,3-METHANOHOMOSERINE GAMMA-LACTONE - A PRECURSOR OF CHIRAL 2,3-METHANOHOMOSERINE

被引：15

作者：

FLICHE, C ^{[1
]}

BRAUN, J ^{[1
]}

LEGOFFIC, F ^{[1
]}

机构：

[1] ECOLE NATL SUPER CHIM,CNRS,UA 1389,BIOORGAN & BIOTECHNOL LAB,11 RUE PIERRE & MARIE CURIE,F-75231 PARIS 05,FRANCE

来源：

SYNTHETIC COMMUNICATIONS | 1991年 / 21卷 / 14期

关键词：

D O I：

10.1080/00397919108016415

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enzymatic hydrolysis of Dimethyl 2 - (tetrahydropyranyl) hydroxymethyl cyclopropane 1,1 - dicarboxylate 6 with an industrial esterase, followed by a deprotection of tetrahydropyranyl ether affords the title compound in 20% yield.

引用

页码：1429 / 1432

页数：4

共 6 条

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AITKEN, DJ ;

ROYER, J ;

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[2] HETERO-SUBSTITUTED METHYLIDENEOXAZOLONES - 2,3-METHANOHOMOSERINE AND METHANOMETHIONINE SYNTHESIS [J].

BLAND, J ;

SHAH, A ;

BORTOLUSSI, A ;

STAMMER, CH .

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[3]

BONGINI A, 1979, SYNTHESIS-STUTTGART, P618

[4] ETHYLENE BIOSYNTHESIS .10. SYNTHESIS AND STUDY OF RACEMIC, (1R,2S)-1-AMINO-2-(HYDROXYMETHYL)CYCLOPROPANECARBOXYLIC AND (1S,2R)-1-AMINO-2-(HYDROXYMETHYL)CYCLOPROPANECARBOXYLIC ACID [J].

PIRRUNG, MC ;

DUNLAP, SE ;

TRINKS, UP .

HELVETICA CHIMICA ACTA, 1989, 72 (06) :1301-1310

[5]

STAMMER CH, 1990, TETRAHEDRON, V46, P2231

[6]

ZEFIROV NS, 1983, ZH ORG KHIM+, V19, P541

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