LONG-TERM EFFECTS OF IMIPRAMINE ON STRIATAL DOPAMINE AUTORECEPTOR FUNCTION - INVOLVEMENT OF BOTH NORADRENERGIC AND SEROTONERGIC SYSTEMS

被引：5

作者：

SCAVONE, C

AIZENSTEIN, ML

PLANETA, CD

DELUCIA, R

机构：

[1] UNIV SAO PAULO, INST CIENCIAS BIOMED,DEPT FARMACOL, NEUROPSICOFARMACOL LAB,CAIXA POSTAL 4365, BR-05508 SAO PAULO, BRAZIL

[2] UNIV NACL ESTADUAL SAO PAULO, DEPT PRINCIPIOS ATIVOS NATURAIS & TOXICOL, SAO PAULO, BRAZIL

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1992年 / 23卷 / 03期

关键词：

D O I：

10.1016/0306-3623(92)90101-O

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The effects of apomorphine (APO) administration on DA system activity were assessed by measuring dopamine metabolite levels (HVA) in several circumstances. 2. Pretreatment with IMI reduced the effect of APO on HVA levels. 3. Pretreatments with either IDE or DMI did not reduce the effect of APO on HVA levels. 4. Reductions of either NE and 5-HT levels after DSP4 and pCPA restored the effect of APO after IMI pretreatment.

引用

页码：397 / 401

页数：5

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