UNUSUAL CHARGE CONFIGURATIONS IN TRANSCRIPTION FACTORS OF THE BASIC RNA POLYMERASE-II INITIATION COMPLEX

被引：21

作者：

KARLIN, S

机构：

[1] Department of Mathematics, Stanford University, Stanford

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 12期

关键词：

D O I：

10.1073/pnas.90.12.5593

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A systematic analysis of the primary sequences of the polymerase II initiation complex has revealed unusual charge features in the TFII family proteins. In particular, the proteins TFIIAalpha, TFIIEalpha, and TFIIF carry multiple charge clusters and hyper charge runs, sequence features occurring in <4% of all (available) eukaryotic proteins. Possible implications for these charge structures are discussed in relation to the assembly and function of the polymerase II transcriptional complex.

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页码：5593 / 5597

页数：5

相关论文

共 39 条

[1] CHARACTERIZATION OF CDNA FOR THE LARGE SUBUNIT OF THE TRANSCRIPTION INITIATION-FACTOR TFIIF [J].

ASO, T ;

VASAVADA, HA ;

KAWAGUCHI, T ;

GERMINO, FJ ;

GANGULY, S ;

KITAJIMA, S ;

WEISSMAN, SM ;

YASUKOCHI, Y .

NATURE, 1992, 355 (6359) :461-464

[2] VERY LONG CHARGE RUNS IN SYSTEMIC LUPUS ERYTHEMATOSUS-ASSOCIATED AUTOANTIGENS [J].

BRENDEL, V ;

DOHLMAN, J ;

BLAISDELL, BE ;

KARLIN, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) :1536-1540

[3] METHODS AND ALGORITHMS FOR STATISTICAL-ANALYSIS OF PROTEIN SEQUENCES [J].

BRENDEL, V ;

BUCHER, P ;

NOURBAKHSH, IR ;

BLAISDELL, BE ;

KARLIN, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (06) :2002-2006

[4] ASSOCIATION OF CHARGE CLUSTERS WITH FUNCTIONAL DOMAINS OF CELLULAR TRANSCRIPTION FACTORS [J].

BRENDEL, V ;

KARLIN, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (15) :5698-5702

[5] TRANSCRIPTION FACTOR-IIA IS INACTIVATED DURING TERMINAL DIFFERENTIATION OF AVIAN ERYTHROID-CELLS [J].

BUNGERT, J ;

WALDSCHMIDT, R ;

KOBER, I ;

SEIFART, KH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (24) :11678-11682

[6] TRANSCRIPTION FACTOR-IID MUTANTS DEFECTIVE FOR INTERACTION WITH TRANSCRIPTION FACTOR-IIA [J].

BURATOWSKI, S ;

ZHOU, H .

SCIENCE, 1992, 255 (5048) :1130-1132

[7] ANIONIC REGIONS IN NUCLEAR PROTEINS [J].

EARNSHAW, WC .

JOURNAL OF CELL BIOLOGY, 1987, 105 (04) :1479-1482

[8] A CDNA-ENCODING RAP74, A GENERAL INITIATION-FACTOR FOR TRANSCRIPTION BY RNA POLYMERASE-II [J].

FINKELSTEIN, A ;

KOSTRUB, CF ;

LI, J ;

CHAVEZ, DP ;

WANG, BQ ;

FANG, SM ;

GREENBLATT, J ;

BURTON, ZF .

NATURE, 1992, 355 (6359) :464-467

[9]

FLROES O, 1992, J BIOL CHEM, V267, P2786

[10] CLONING OF A SUBUNIT OF YEAST RNA POLYMERASE-II TRANSCRIPTION FACTOR-B AND CTD KINASE [J].

GILEADI, O ;

FEAVER, WJ ;

KORNBERG, RD .

SCIENCE, 1992, 257 (5075) :1389-1392

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